For once David Axelrod is right!
YES! This is what libertarians have been saying for years. The government is so vast and intrusive it is impossible to be managed well (if at all) and even the best of intentions can go very very wrong and the answer to all of it is smaller government. Less regulation and more liberty. Let California be California and let Utah be Utah. Push the 10th Amendment and make it count. Encourage California and Colorado's marijuana laws even if you don't agree with them for your state. It is about constraining the Feds to their proper federal role and not having them insert themselves in every aspect of your life.